The Promotive Effects of Thymosin β4 on Neuronal Survival and Neurite Outgrowth by Upregulating L1 Expression.
Yang H, Cheng X, Yao Q, Li J, Ju G.
Neurochem Research, May 7, 2008.
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Thymosin β4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection.
Hinkel R, El-Aouni C, Olson T, Horstkotte J, Mayer S, Müller S, Willhauck M, Spitzweg C, Gildehaus FJ, Münzing W, Hannappel E, Bock-Marquette I, DiMaio JM, Hatzopoulos AK, Boekstegers P, Kupatt C.
Circulation. 2008 Apr 29;117(17):2232-40. Epub 2008 Apr 21.
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Proteinase and Growth Factor Alterations Revealed by Gene Microarray Analysis of Human Diabetic Corneas
Mehrnoosh Saghizadeh, ^{1, 2} Andrei A. Kramerov, ¹ Jian Tajbakhsh, ² Annette M. Aoki, ¹ Charles Wang, ^2,3 Ning-Ning Chai, ³ Julia Y. Ljubimova, ⁴ Takako Sasaki, ⁵ Gabriel Sosne,⁶ Marc R. J. Carlson,² Stanley F. Nelson,² and Alexander V. Ljubimov^1,2
Invest Ophthalmol Vis Sci. 2005 Oct; 46(10):3604-15
¹Ophthalmology Research Laboratories, ³Research Institute Microarray Core, and ⁴Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California; ²David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California; ⁵Max-Planck-Institut für Biochemie, Martinsried, Germany; and ⁶Departments of Ophthalmology, and Anatomy and Cell Biology, Wayne State University, Detroit, Michigan.
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Thymosin β4: actin-sequestering protein moonlights to repair injured tissues
Allan L. Goldstein,¹ Ewald Hannappe^l,2, and Hynda K. Kleinman³
Trends Mol Med. 2005 Sep; 11(9):421-9
¹Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Sciences, 2300 I. Street, NW, Washington, D.C. 20037, USA
²Universitat Erlangen, Inst. f. Biochemie, Fahrstr. 17, 91054 Erlangen, Germany
³Cell Biology Section, NIDCR, NIH, Bldg. 30, Room 433, 30 Convent Drive, MSC-4370, Bethesda, MD 20892, USA
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Thymosin β4 Modulates Corneal Matrix Metalloproteinase Levels and Polymorphonuclear Cell Infiltration after Alkali Injury
Gabriel Sosne,^{1, 2} Patricia L. Christopherson,¹ Ronald P. Barret,² and Rafael Fridman³
Invest Ophthalmol Vis Sci. 2005 Jul; 46(7):2388-95
¹Department of Ophthalmology, Kresge Eye Institute,Detroit, Michigan; and the Departments of ²Anatomy and Cell Biology and ³Pathology, Wayne State University, Detroit, Michigan.
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Phylogenetic analysis and developmental expression of thymosin-β4 gene in amphioxus.
Huang X¹, Zhang W¹, Zhang H¹
Dev Genes Evol. 2005 Jul; 215(7):364-8. Epub 2005 Mar 24.
(1) Department of Biology, Shandong University, Shandong, Jinan, 250100, People's Republic of China
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Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair.
Bock-Marquette I, Saxena A, White MD, DiMaio JM, Srivastava D.
NATURE. 2004 NOV 25;432(7016):466-72.
Department of Pediatrics, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, Texas 75390-9148, USA.
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Thymosin beta 4 stimulates laminin-5 production independent of TGF-beta
Gabriel Sosne,^a,b, Lihua Xu,^a Lisa Prach,^a Linda K. Mrock,^a Hynda K. Kleinman,^c John J. Letterio,^d Linda D. Hazlett,^a and Michelle Kurpakus-Wheater^a
Experimental Cell Research 293 (2004),178-183
^aDepartment of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA
^bDepartment of Ophthalmology, Kresge Eye Institute, Wayne State University, Detroit, MI, USA
^cNIDCR/NIH, Bethesda, MD, USA
^dNCI/NIH, Bethesda, MD, USA
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Factor XIIIa incorporates Thymosin β4 Preferentially into the Fibrin(ogen) αC-Domains†
Evgeny Makogonenko,^‡ Allan L. Goldstein,^§ Paul D. Bishop,^װ and Leonid Medved^{*,‡, §}
AMERICAN CHEMICAL SOCIETY 2004 Vol. 43, Issue 33, pages 10748-10756
Biochemistry Department, Jerome H. Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Services, Washington, D.C. and ZymoGenetics, Inc. Seattle, Washington
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Thymosin-β4 Inhibits Corneal Epithelial Cell Apoptosis after Ethanol Exposure In Vitro
Gabriel Sosne,^1,2 Atif Siddiqi,¹ and Michelle Kurpakus-Wheater¹
INVST OPTHALMOL VIS SCI, 2004;45:1095-1100
¹Department of Anatomy and Cell Biology
²Ophthalmology, Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan
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Thymosin β4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice
Deborah Philp, PhD, Mahnaz Badamchian, PhD, Brooke Schermeta, Mychi Nguyen, Allan L. Goldstein, PhD., Hynda K. Kleinman, PhD.
WOUND REP REG, 2003;19-24
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Thymosin β4 Promotes Human Conjunctival Epithelial Cell Migration
Gabriel Sosne^1,2 , Saif Hafeez², Albert L. Greenberry², and Michelle Kurpakus-Wheater²
Curr Eye Res. 2002 Apr;24(4):268-73.
¹ Kresge Eye Institute, Detroit, MI, USA
² Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI USA 2002
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Thymosin β4 is released from human blood platelets and attached by factor XIIIa (transglutaminase) to fibrin and collagen
Thomas Huff, Angela M. Otto, Christian S.G. Müller, Markus Meier, and Ewald Hannapel
FASEB J. 16, 691-696 (2002)
¹Institute of Biochemistry, Faculty of Medicine, University Erlangen-Nuremberg, 91054 Erlangen, Germany
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Thymosin Beta 4 Promotes Corneal Wound Healing and Decreases Inflammation in Vivo Following Alkali Injury
Gabriel Sosne^a, Elizabeth A. Szliter^b, Ronald Barrett^b, Karen A. Kernacki^b, Hynda Kleinman^c, Linda D. Hazlett^b
Exp Eye Res. 2002 Feb;74(2):293-9.
^aEye Care Services Department, Henry Ford Hospital, Detroit, MI, 48202, U.S.A.
^bDepartment of Anatomy and Cell Biology, Wayne State University, Detroit, MI, U.S.A.
^cLaboratory of Developmental Biology, National Institute for Dental and Craniofacial Research, NIH, Bethesda, MD, U.S.A.
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Thymosin Beta 4 Promotes Corneal Wound Healing and Modulates Inflammatory Mediators in vivo
Sosne G, Chan CC, Thai K, Kennedy M, Szliter EA, Hazlett LD, Kleinman HK
Exp Eye Res. 2001 May;72(5):605-8.
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Thymosin Beta(4) Serves as a Glutaminyl Substrate of Transglutaminase. Labeling with Fluorescent Dansylcadaverine Does Not Abolish Interaction with G-actin.
Huff T; Ballweber E; Humeny A; Bonk T; Becker C; Muller CS; Mannherz HG; Hannappel E
FEBS Lett 1999 Dec 24;464(1-2):14-20
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Thymosin Beta 4 Accelerates Wound Healing.
Malinda KM; Sidhu GS; Mani H; Banaudha K; Maheshwari RK; Goldstein AL; Kleinman HK
J Invest Dermatol. 1999 Sep;113(3):364-8.
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